MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded within the mitochondrial genome’s 12S rRNA region and is classified as a mitochondria-derived peptide (MDP). Experimental investigations have examined its role in mitochondrial-to-nuclear signaling pathways, intracellular regulatory networks, and adaptive signaling mechanisms associated with mitochondrial communication systems. Research has also explored interactions with AMP-activated protein kinase (AMPK), FOXO-associated signaling pathways, transcriptional regulatory processes, and downstream signal transduction networks. Research applications include mitochondrial signaling pathway investigation, AMPK pathway characterization, FOXO signaling studies, mitochondrial communication research, and mechanistic evaluation of mitochondria-derived peptide biology.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
MOTS-C is a 16-amino-acid peptide (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg; MRWQEMGYIFYPRKLR) encoded within the 12S rRNA region of the mitochondrial genome, making it one of a limited number of peptides derived from mitochondrial DNA. Experimental investigations have examined its role in mitochondrial-to-nuclear communication pathways, intracellular regulatory networks, and signaling mechanisms associated with mitochondrial function. Research has reported interactions with AMP-activated protein kinase (AMPK), FOXO-associated signaling pathways, transcriptional regulatory processes, and downstream signal transduction networks involved in cellular adaptation mechanisms. Additional studies have explored the relationship between MOTS-C and nuclear localization pathways, antioxidant response element (ARE)-associated signaling, and molecular processes governing mitochondrial communication systems. These characteristics have established MOTS-C as a valuable research tool for investigating mitochondria-derived peptide biology, mitochondrial signaling networks, transcriptional regulation, and mechanistic aspects of mitochondrial-nuclear signaling crosstalk. Supplied as a lyophilized preparation. Independently third-party HPLC-tested; COA available per batch.
